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Article

p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.

American journal of respiratory cell and molecular biology - 1 Jun 2010

Deng Huan, Hershenson Marc B, Lei Jing, Bitar Khalil N, Fingar Diane C, Solway Julian, Bentley J Kelley

Abstract excerpt

We examined the contribution of p70 ribosomal S6 kinase (p70S6K) to airway smooth muscle hypertrophy, a structural change found in asthma. In human airway smooth muscle cells, transforming growth factor (TGF)-beta, endothelin-1, and cardiotrophin-1 each induced phosphorylation of p70S6K and ribosomal protein S6 while increasing cell size, total protein synthesis, and relative protein abundance of alpha-smooth...

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Identifiers

PMID: 19648476
DOI: 10.1165/rcmb.2009-0037OC
PMCID: PMC2891500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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