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Article

Expression and characterization of recombinant soluble monkey CD3 molecules: mapping the FN18 polymorphic epitope.

Molecular immunology - 1 Mar 2004

Wang Zhirui, Neville David M

Abstract excerpt

The monoclonal antibody FN18 has been used as a marker for monkey T cells and as a T cell depleting reagent when conjugated to binding site mutants of diphtheria toxin. This anti-CD3 antibody shares certain properties with its anti-human counterparts UCHT1, OKT3 and Leu-4 in that it precipitates two different CD3 chains from membrane detergent extracts. However, in contrast to human CD3, rhesus and cynomolgus...

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PMID: 15104123
DOI: 10.1016/j.molimm.2003.11.025

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