Article
Mutations in beta-spectrin disrupt axon outgrowth and sarcomere structure.
The Journal of cell biology - 15 May 2000
Hammarlund M, Davis W S, Jorgensen E M
Abstract excerpt
beta-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. beta-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caenorhabditis elegans homologue of beta-spectrin is encoded by the unc-70 gene. unc-70 null mutants develop slowly,...
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