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Article

Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.

The Journal of biological chemistry - 2 Jul 2004

Tsushima Shuichi, Kai Masahiro, Yamada Keiko, Imai Shin-ichi, Houkin Kiyohiro, Kanoh Hideo, Sakane Fumio

Abstract excerpt

Nine diacylglycerol kinase (DGK) isozymes have been identified. However, our knowledge of their individual functions is still limited. Here, we demonstrate the role of DGKgamma in regulating Rac1-governed cell morphology. We found that the expression of kinase-dead DGKgamma, which acts as a dominant-negative mutant, and inhibition of endogenous DGKgamma activity with R59949 induced lamellipodium and membrane...

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Identifiers

PMID: 15102830
DOI: 10.1074/jbc.M314031200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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