Article
Comparative study of brain CD8+ T cells induced by sporozoites and those induced by blood-stage Plasmodium berghei ANKA involved in the development of cerebral malaria.
Infection and immunity - 1 May 2004
Bagot Sébastien, Nogueira Fatima, Collette Alexis, do Rosario Virgilio, Lemonier François, Cazenave Pierre-André, Pied Sylviane
Abstract excerpt
To obtain insight into the mechanisms that contribute to the pathogenesis of Plasmodium infections, we developed an improved rodent model that mimics human malaria closely by inducing cerebral malaria (CM) through sporozoite infection. We used this model to carry out a detailed study on isolated T cells recruited from the brains of mice during the development of CM. We compared several aspects of the immune...
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