Article
IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2013
Ball Elizabeth Ann, Sambo Maria Rosário, Martins Madalena, Trovoada Maria Jesus, Benchimol Carla, Costa João, Antunes Gonçalves Lígia, Coutinho António, Penha-Gonçalves Carlos
Abstract excerpt
Development of cerebral malaria (CM), a severe and fatal form of clinical Plasmodium falciparum infection, results from a damaging cascade of vascular, inflammatory, and immunological host responses that leads to brain injury. Progression to CM can be modified by host genetic factors. Our case-control study in Angolan children aimed at highlighting the role of IFN (α, β) receptor 1 (IFNAR1) in progression to CM....
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