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Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria

28 Apr 2011

Abstract excerpt

Parasite burden predicts disease severity in malaria and risk of death in cerebral malaria patients. In murine experimental cerebral malaria (ECM), parasite burden and CD8(+) T cells promote disease by mechanisms that are not fully understood. We found that the majority of brain-recruited CD8(+) T cells expressed granzyme B (GzmB). Furthermore, gzmB(-/-) mice harbored reduced parasite numbers in the brain as a...

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PMID: 21525386
DOI: 10.4049/jimmunol.1003955

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