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Article

Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2003

Nitcheu Josianne, Bonduelle Olivia, Combadiere Christophe, Tefit Maurel, Seilhean Danielle, Mazier Dominique, Combadiere Behazine

Abstract excerpt

Experimental cerebral malaria (ECM) resulting from Plasmodium berghei ANKA infection involves T lymphocytes. However, the mechanisms of T cell-mediated pathogenesis remain unknown. We found that, in contrast to ECM-susceptible C57BL6 mice, perforin-deficient (PFP-KO) mice were resistant to ECM in the absence of brain lesions, whereas cytoadherence of parasitized erythrocytes and massive accumulation of...

Topics

Adoptive Transfer
Animals
Brain
CD4-Positive T-Lymphocytes
Cell Differentiation
Cell Movement
Female
Fluoresceins
Genetic Predisposition to Disease
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunologic Memory

Malaria, Cerebral

Membrane Glycoproteins

Mice

Mice, Inbred C57BL

Mice, Knockout

Perforin

Plasmodium berghei

Source

Identifiers

PMID: 12574396
DOI: 10.4049/jimmunol.170.4.2221

Genes

CCR5

Provenance

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