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Article

Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2003

Nitcheu Josianne, Bonduelle Olivia, Combadiere Christophe, Tefit Maurel, Seilhean Danielle, Mazier Dominique, Combadiere Behazine

Abstract excerpt

Experimental cerebral malaria (ECM) resulting from Plasmodium berghei ANKA infection involves T lymphocytes. However, the mechanisms of T cell-mediated pathogenesis remain unknown. We found that, in contrast to ECM-susceptible C57BL6 mice, perforin-deficient (PFP-KO) mice were resistant to ECM in the absence of brain lesions, whereas cytoadherence of parasitized erythrocytes and massive accumulation of...

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Source

Identifiers

PMID: 12574396
DOI: 10.4049/jimmunol.170.4.2221

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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