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Development of a Novel CD4 + TCR Transgenic Line that Reveals a Dominant Role for CD8 + DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria

2017-03-03

Abstract excerpt

We describe an MHC II (IA b )-restricted T cell receptor (TCR) transgenic mouse line that produces CD4 + T cells specific for Plasmodium species. This line, termed PbT-II, was derived from a CD4 + T cell hybridoma generated to blood-stage Plasmodium berghei ANKA (PbA). PbT-II cells responded to all Plasmodium species and stages tested so far, including rodent (PbA, P. berghei NK65, P. chabaudi AS and P. y...

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Literature Corpus work: 2e9debb3-361d-513c-afa2-d2e5d3a5fe89
DOI: 10.1101/113837

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Development of a Novel CD4 <sup>+</sup> TCR Transgenic Line that Reveals a Dominant Role for CD8 <sup>+</sup> DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria

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