Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll‐Like Receptor Modulation of Murine Cerebral Malaria Is Dependent on the Genetic Background of the Host

15 Nov 2007

Abstract excerpt

Infection with Plasmodium berghei ANKA is a well-established model of human cerebral malaria (CM). We show herein that Toll-like receptor (TLR) signaling influences the development of lethal CM in P. berghei ANKA-infected mice. Modulation of outcome was dependent on genetic background, such that deletion of myeloid differentiation factor (MyD) 88 on the susceptible C57BL/6 background resulted in resistance to CM,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18008236
DOI: 10.1086/522865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll‐Like Receptor Modulation of Murine Cerebral Malaria Is Dependent on the Genetic Background of the HostPMID 18008236Read ↗

γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infectionSemantic proximity Read ↗

IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice.Semantic proximity Read ↗

Pathogenic CD8+ T cells in experimental cerebral malaria.Semantic proximity Read ↗

Profiles of cytokine production in relation with susceptibility to cerebral malaria.Semantic proximity Read ↗

Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis.Semantic proximity Read ↗

Protective and pathogenic roles of CD8+ T cells during malaria infectionSemantic proximity Read ↗

Cerebral malaria in mice: interleukin-2 treatment induces accumulation of gammadelta T cells in the brain and alters resistant mice to susceptible-like phenotype.Semantic proximity Read ↗

Comparative study of brain CD8+ T cells induced by sporozoites and those induced by blood-stage Plasmodium berghei ANKA involved in the development of cerebral malaria.Semantic proximity Read ↗

Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice.Semantic proximity Read ↗

Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.Semantic proximity Read ↗

L-arginine exacerbates experimental cerebral malaria by enhancing pro-inflammatory responses.Semantic proximity Read ↗

Cerebral malaria is regulated by host mediated changes in <i>Plasmodium</i> gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.