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Article

In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants.

Infection and immunity - 1 May 2004

Young Vincent B, Knox Kimberly A, Pratt Jason S, Cortez Jennifer S, Mansfield Linda S, Rogers Arlin B, Fox James G, Schauer David B

Abstract excerpt

Helicobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family of bacterial cytotoxins. To investigate the role of CDT in the pathogenesis of H. hepaticus, transposon mutagenesis was used to generate a series of isogenic mutants in and around the cdtABC gene cluster. An H. hepaticus transposon mutant with a disrupted cdtABC coding region no longer produced CDT activity. Conversely, a...

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Identifiers

PMID: 15102759
DOI: 10.1128/IAI.72.5.2521-2527.2004
PMCID: PMC387909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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