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Article

The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transition

2022-04-06

Abstract excerpt

We are frequently exposed to bacterial genotoxins, such as cytolethal distending toxin (CDT), a prevalent heterotrimeric toxin whose active moiety is its CdtB subunit. CdtB triggers potent DNA damage, predisposing factors in the development of cancers, in host cells. CDT from Helicobacter hepaticus , a mouse pathogen, was shown to be directly involved in the development of murine hepatocarcinoma. Preliminary stud...

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Literature Corpus work
02d641cd-d5e8-5a44-b617-575a0d47b108
DOI
10.1101/2022.04.06.487255
Open publication

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The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transitionDOI 10.1101/2022.04.06.487255
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