Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.

Cellular microbiology - 1 Aug 2007

Ge Zhongming, Rogers Arlin B, Feng Yan, Lee Amy, Xu Shilu, Taylor Nancy S, Fox James G

Abstract excerpt

Bacterial cytolethal distending toxins (CDTs) containing DNase I-like activity can induce limited host DNA damage that leads to activation of the DNA-damage repair responses in cultured cell lines. However, in vivo experimental evidence linking CDTs to carcinogenesis is lacking. In this study, infection of A/JCr mice with an isogenic mutant of Helicobacter hepaticus lacking CDT activity (CDT mutant) induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Toxins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Helicobacter Infections

Share to Hepatitis, Chronic

Share to Hepatocytes

Share to Transcriptional Activation

Source

Identifiers

PMID: 17441986
DOI: 10.1111/j.1462-5822.2007.00939.x

Genes

MPI
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.PMID 17441986Read ↗

Helicobacter hepaticuscytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient miceSemantic proximity Read ↗

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell LinesSemantic proximity Read ↗

The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transitionSemantic proximity Read ↗

The Cytolethal Distending Toxin Subunit CdtB of Helicobacter Induces a Th17-related and Antimicrobial Signature in Intestinal and Hepatic Cells In Vitro.Semantic proximity Read ↗

Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus.Semantic proximity Read ↗

Helicobacter hepaticus Induce Colitis in Male IL-10−/− Mice Dependent by Cytolethal Distending Toxin B and via the Activation of Jak/Stat Signaling PathwaySemantic proximity Read ↗

The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1Semantic proximity Read ↗

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal CarcinogenesisSemantic proximity Read ↗

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxinSemantic proximity Read ↗

In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants.Semantic proximity Read ↗

Cytolethal Distending Toxin Sequence and Activity in the Enterohepatic PathogenHelicobacter hepaticusSemantic proximity Read ↗

Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.