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Article

Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.

Cellular microbiology - 1 Aug 2007

Ge Zhongming, Rogers Arlin B, Feng Yan, Lee Amy, Xu Shilu, Taylor Nancy S, Fox James G

Abstract excerpt

Bacterial cytolethal distending toxins (CDTs) containing DNase I-like activity can induce limited host DNA damage that leads to activation of the DNA-damage repair responses in cultured cell lines. However, in vivo experimental evidence linking CDTs to carcinogenesis is lacking. In this study, in...

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Source

Identifiers

PMID: 17441986
DOI: 10.1111/j.1462-5822.2007.00939.x

Genes

MPI
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17441986-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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