Article
Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens.
Infection and immunity - 1 May 2005
Abuoun Manal, Manning Georgina, Cawthraw Shaun A, Ridley Anne, Ahmed If H, Wassenaar Trudy M, Newell Diane G
Abstract excerpt
The cytolethal distending toxin (CDT) of Campylobacter jejuni was detectable, using an in vitro assay, in most but not all of 24 strains tested. The reason for the absence of toxin activity in these naturally occurring CDT-negative C. jejuni strains was then investigated at the genetic level. CDT is encoded by three highly conserved genes, cdtA, -B, and -C. In the CDT-negative strains, two types of mutation were...
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