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Cytolethal Distending Toxin Sequence and Activity in the Enterohepatic PathogenHelicobacter hepaticus

1 Jan 2000

Abstract excerpt

Little is known about the molecular pathogenesis of hepatitis and enterocolitis caused by enterohepatic Helicobacter species. Sonicates of the murine pathogen Helicobacter hepaticus were found to cause progressive cell distension, accumulation of filamentous actin, and G(2)/M cell cycle arrest in HeLa cell monolayers. The genes encoding this cytotoxic activity were cloned from H. hepaticus. Three open reading...

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PMID: 10603386
DOI: 10.1128/iai.68.1.184-191.2000

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