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Article

Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin.

Infection and immunity - 1 Aug 1999

Stevens M K, Latimer J L, Lumbley S R, Ward C K, Cope L D, Lagergard T, Hansen E J

Abstract excerpt

Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that kills HeLa, HEp-2, and other human epithelial cells in vitro. H. ducreyi CDT activity is encoded by a three-gene cluster (cdtABC), and antibody to the cdtC gene product can neutralize CDT activity in vitro (L. D. Cope, S. R. Lumbley, J. L. Latimer, J. Klesney-Tait, M. K. Stevens, L. S. Johnson, M. Purven, R. S. Munson, Jr., T....

Topics

Animals
Antibodies, Monoclonal
Bacterial Toxins
Female
Haemophilus ducreyi
HeLa Cells
Humans
Male
Mice
Mice, Inbred BALB C
Multigene Family
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Virulence

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Identifiers

PMID: 10417154
DOI: 10.1128/IAI.67.8.3900-3908.1999
PMCID: PMC96670

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Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin.PMID 10417154Read ↗

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