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Article

Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus.

Infection and immunity - 1 Aug 2006

Pratt Jason S, Sachen Kacey L, Wood Heather D, Eaton Kathryn A, Young Vincent B

Abstract excerpt

Persistent murine infection with Helicobacter hepaticus leads to chronic gastrointestinal inflammation and neoplasia in susceptible strains. To determine the role of the virulence factor cytolethal distending toxin (CDT) in the pathogenesis of this organism, interleukin-10-deficient (IL-10-/-) mice were experimentally infected with wild-type H. hepaticus and a CDT-deficient isogenic mutant. Both wild-type H....

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Identifiers

PMID: 16861635
DOI: 10.1128/IAI.00503-06
PMCID: PMC1539592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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