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Helicobacter hepaticuscytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient mice

23 Jan 2017

Abstract excerpt

Multiple pathogenic Gram-negative bacteria produce the cytolethal distending toxin (CDT) with activity of DNase I; CDT can induce DNA double-strand breaks (DSBs), G2/M cell cycle arrest, and apoptosis in cultured mammalian cells. However, the link of CDT to in vivo tumorigenesis is not fully understood. In this study, 129/SvEv Rag2−/− mice were gavaged with wild-type Helicobacter hepatics 3B1(Hh) and its isogenic...

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PMID: 28111881
DOI: 10.1111/cmi.12728

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