Article
Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
BMC psychiatry - 4 Mar 2004
Jönsson Erik G, Bah Jessica, Melke Jonas, Abou Jamra Rami, Schumacher Johannes, Westberg Lars, Ivo Roland, Cichon Sven, Propping Peter, Nöthen Markus M, Eriksson Elias, Sedvall Göran C
Abstract excerpt
BACKGROUND: Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. CSF monoamine metabolite concentrations are partly determined by genetic influences. METHODS: We investigated possible relationships between DNA polymorphisms in the serotonin 2C receptor (HTR2C), the serotonin 3A receptor (HTR3A), the dopamine...
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