Article
Dopamine-related genes and their relationships to monoamine metabolites in CSF.
Biological psychiatry - 15 Nov 1996
Jönsson E, Sedvall G, Brené S, Gustavsson J P, Geijer T, Terenius L, Crocq M A, Lannfelt L, Tylec A, Sokoloff P, Schwartz J C, Wiesel F A
Abstract excerpt
Monoamine metabolite (MM) levels in lumbar cerebrospinal fluid (CSF) are extensively used as indirect estimates of monoamine turnover in the brain. In this study we investigated genotypes for DNA polymorphisms in the D2 (DRD2), D3 (DRD3), and D4 (DRD4) dopamine receptor and tyrosine hydroxylase (...
Topics
- Adult
- Biogenic Monoamines
- Cerebrospinal Fluid
- Dopamine
- Female
- Genotype
- Homovanillic Acid
- Humans
- Hydroxyindoleacetic Acid
- Male
- Mental Disorders
- Methoxyhydroxyphenylglycol
- Middle Aged
- Polymorphism, Genetic
- Receptors, Dopamine