HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses.

doi:10.1016/s0006-3223(98)00361-8

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Article

HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses.

Biological psychiatry - 15 Sept 1999

Lappalainen J, Long J C, Virkkunen M, Ozaki N, Goldman D, Linnoila M

Abstract excerpt

BACKGROUND: Heritable variation in brain monoaminergic activity has been suggested to lead to interindividual differences in vulnerability to alcoholism, and many other behavioral disorders. We evaluated if a functional Cys23Ser polymorphism in the 5-HT2C receptor gene, the principal serotonin receptor in the brain, contributes to variation in serotonin, norepinephrine and dopamine activity, as indexed by their...

Topics

Alcoholism
Biogenic Monoamines
Brain
Dopamine
Genes
Genotype
Homovanillic Acid
Humans
Hydroxyindoleacetic Acid
Male
Mental Disorders
Methoxyhydroxyphenylglycol
Norepinephrine
Polymorphism, Genetic
Psychiatric Status Rating Scales
Receptors, Serotonin

Source

Open in PubMed

Identifiers

PMID: 10494451
DOI: 10.1016/s0006-3223(98)00361-8

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