Article
Initial stages of mammary tumor virus infection are superantigen independent.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2004
Pobezinskaya Yelena, Chervonsky Alexander V, Golovkina Tatyana V
Abstract excerpt
Exogenous mouse mammary tumor virus (MMTV) is transmitted via the milk from infected mothers to newborn pups. Efficient MMTV transmission is dependent on proliferation of T cells with particular TCR beta-chains, which occurs upon recognition of virally encoded superantigen (SAg) bound to MHC class II molecules. It is assumed that infection of these dividing cells favors MMTV amplification. SAg is important for...
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