Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.

doi:10.1084/jem.180.6.2347

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.

The Journal of experimental medicine - 1 Dec 1994

Held W, Waanders G A, Acha-Orbea H, MacDonald H R

Abstract excerpt

Mouse mammary tumor virus (MMTV) encodes a superantigen (SAg) that promotes stable infection and virus transmission. Upon subcutaneous MMTV injection, infected B cells present SAg to SAg-reactive T cells leading to a strong local immune response in the draining lymph node (LN) that peaks after 6 d. We have used the reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine (AZT) to dissect in more detail the...

Topics

Animals
B-Lymphocytes
CD4-Positive T-Lymphocytes
DNA, Viral
Kinetics
Lymph Nodes
Mammary Tumor Virus, Mouse
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Superantigens

T-Lymphocytes

Virus Replication

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 7525852
DOI: 10.1084/jem.180.6.2347
PMCID: PMC2191775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7525852-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.PMID 7525852Read ↗

Initial stages of mammary tumor virus infection are superantigen independent.Semantic proximity Read ↗

Characterization of two infectious mouse mammary tumour viruses: superantigenicity and tumorigenicity.Semantic proximity Read ↗

Endogenous Mouse Mammary Tumor Viruses (Mtv): New Roles for an Old Virus in Cancer, Infection, and ImmunitySemantic proximity Read ↗

Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.Semantic proximity Read ↗

[Superantigens and murine mammary tumor retrovirus].Semantic proximity Read ↗

The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development.Semantic proximity Read ↗

Mutational and functional analysis of the C-terminal region of the C3H mouse mammary tumor virus superantigen.Semantic proximity Read ↗

The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis.Semantic proximity Read ↗

Mouse mammary tumor virus superantigens require N-linked glycosylation for effective presentation to T cells.Semantic proximity Read ↗

A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice.Semantic proximity Read ↗

Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies.Semantic proximity Read ↗

A Mouse Mammary Tumor Virus-Like Long Terminal Repeat Superantigen in Human Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.