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Article

Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.

The Journal of experimental medicine - 1 Dec 1994

Held W, Waanders G A, Acha-Orbea H, MacDonald H R

Abstract excerpt

Mouse mammary tumor virus (MMTV) encodes a superantigen (SAg) that promotes stable infection and virus transmission. Upon subcutaneous MMTV injection, infected B cells present SAg to SAg-reactive T cells leading to a strong local immune response in the draining lymph node (LN) that peaks after 6 d. We have used the reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine (AZT) to dissect in more detail the...

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Identifiers

PMID: 7525852
DOI: 10.1084/jem.180.6.2347
PMCID: PMC2191775

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