Article
Gene-specific modulation of TAF10 function by SET9-mediated methylation.
Molecular cell - 23 Apr 2004
Kouskouti Antigone, Scheer Elisabeth, Staub Adrien, Tora Làszlò, Talianidis Iannis
Abstract excerpt
SET9 is a member of the SET domain-containing histone methyltransferase family that can specifically methylate histone 3 at lysine 4 position. Although nucleosomal histones are poor substrates for SET9, the active enzyme can stimulate activator-induced transcription. Here, we show that SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the...
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