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Article

A homeotic mutation in the trithorax SET domain impedes histone binding.

Genes & development - 1 Sept 2001

Katsani K R, Arredondo J J, Kal A J, Verrijzer C P

Abstract excerpt

Trithorax (TRX) is a Drosophila SET domain protein that is required for the correct expression of homeotic genes. Here, we show that the TRX SET domain efficiently binds to core histones and nucleosomes. The primary target for the SET domain is histone H3 and binding requires the N-terminal histone tails. The previously described trx(Z11) mutation changes a strictly conserved glycine in the SET domain to serine...

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Identifiers

PMID: 11544176
DOI: 10.1101/gad.201901
PMCID: PMC312775

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A homeotic mutation in the trithorax SET domain impedes histone binding.PMID 11544176Read ↗

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