Article
Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.
Oncogene - 19 Sept 1996
Steenbergen R D, Walboomers J M, Meijer C J, van der Raaij-Helmer E M, Parker J N, Chow L T, Broker T R, Snijders P J
Abstract excerpt
This study aimed at resolving cellular genetic alterations in the process of in vitro immortalization of human keratinocytes by human papillomavirus (HPV) types 16 and 18. Four cell lines of primary human foreskin keratinocytes transfected with HPV 16 and HPV 18, respectively, were analysed during the transition from the mortal to immortal state. All cell lines showed strong telomerase activity at the immortal...
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