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Article

Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of Proliferation

1 Sept 2000

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 10964501
DOI: 10.1006/excr.2000.4982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of ProliferationPMID 10964501Read ↗

Use of exogenous hTERT to immortalize primary human cellsSemantic proximity Read ↗

Cultured human amniocytes express hTERT, which is distributed between nucleus and cytoplasm and is secreted in extracellular vesiclesSemantic proximity Read ↗

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpartSemantic proximity Read ↗

Transient Expression of Human Telomerase Extends the Life Span of Normal Human FibroblastsSemantic proximity Read ↗

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cellsSemantic proximity Read ↗

Lack of telomerase activity in human mesenchymal stem cellsSemantic proximity Read ↗

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblastsSemantic proximity Read ↗

Stabilization of cellular properties and differentiation mutilpotential of human mesenchymal stem cells transduced with hTERT gene in a long‐term cultureSemantic proximity Read ↗

Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transferSemantic proximity Read ↗

Characterization and validation of long-term cultured TERT-immortalized human Wharton’s jelly–derived mesenchymal stromal cellsSemantic proximity Read ↗

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma CellsSemantic proximity Read ↗

Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation.Semantic proximity Read ↗

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