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Immortalized cells and one oncogene in malignant transformation: old insights on new explanation

23 May 2011

Abstract excerpt

BACKGROUND: Nearly thirty years ago, it was first shown that malignant transformation with single oncogene necessarily requires the immortal state of the cell. From that time this thesis for the cells of human origin was not disproved. The basic point which we want to focus on by this short communication is the correct interpretation of the results obtained on the widely used human embryonic kidney 293 (HEK293)...

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PMID: 21605454
DOI: 10.1186/1471-2121-12-23

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