Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain.

doi:10.1016/j.mcn.2003.10.012

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Article

Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain.

Molecular and cellular neurosciences - 1 Apr 2004

Héron-Milhavet Lisa, Xue-Jun Yang, Vannucci Susan J, Wood Teresa L, Willing Lisa B, Stannard Bethel, Hernandez-Sanchez Catalina, Mobbs Charles, Virsolvy Anne, LeRoith Derek

Abstract excerpt

The role of the K-ATP channel pore-forming subunit Kir6.2 on protection from cerebral hypoxic-ischemic injury was assessed in transgenic mice overexpressing normal Kir6.2 or a dominant negative form (AFA) of this subunit in the forebrain. The resulting mice overexpress either the Kir6.2 or the AFA transgene mainly in the cerebral cortex and hippocampus. The Kir6.2 transgenic mice are resistant to hypoxic-ischemic...

Topics

Action Potentials
Animals
Cerebral Cortex
Cerebral Infarction
Hippocampus
Hypoxia-Ischemia, Brain
Immunity, Innate
Mice
Mice, Transgenic
Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Phenotype

Potassium Channels, Inwardly Rectifying

Prosencephalon

Sulfonylurea Compounds

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 15080888
DOI: 10.1016/j.mcn.2003.10.012

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