Article
Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice.
Brain research. Molecular brain research - 15 Dec 1997
Le D, Das S, Wang Y F, Yoshizawa T, Sasaki Y F, Takasu M, Nemes A, Mendelsohn M, Dikkes P, Lipton S A, Nakanishi N
Abstract excerpt
Excitatory amino acid (EAA) receptors play an important role in neuronal cell death in acute cerebral ischemia. Blocking the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of EAA receptor has been shown to reduce cell death in global cerebral ischemia. However their role in focal stroke, although suggestive, has remained more contentious. To clarify this issue, we generated transgenic mice...
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