Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury.

doi:10.1016/j.neuroscience.2015.11.035

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Article

Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury.

Neuroscience - 28 Jan 2016

Kim T Y, Yoshimoto T, Aoyama Y, Niimi K, Takahashi E

Abstract excerpt

We previously reported that rolling Nagoya mice carrying a mutation in the α1 subunit of the Cav2.1 channel protective from ischemia- and kainate-induced neuronal damage. However, the protective effect of this mutation and its relationship to brain injury recovery have not been examined. To examine the relationship between Cav2.1 channel function and brain injury, we induced cryogenic brain damage in homozygous...

Topics

Animals
Astrocytes
Blood-Brain Barrier
Brain Injuries
Calcium Channel Blockers
Calcium Channels, N-Type
Capillary Permeability
Cold Temperature
Disease Models, Animal
Male
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Degeneration

Neurons

Neuroprotective Agents

Phosphorylation

p38 Mitogen-Activated Protein Kinases

Source

Open in PubMed

Identifiers

PMID: 26616403
DOI: 10.1016/j.neuroscience.2015.11.035

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