Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.

doi:10.1016/j.nbd.2007.10.003

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Article

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.

Neurobiology of disease - 1 Mar 2008

Torres-Peraza Jesús F, Giralt Albert, García-Martínez Juan M, Pedrosa Edurne, Canals Josep M, Alberch Jordi

Abstract excerpt

We study the striatal susceptibility to NMDA receptor (NMDAR)-mediated injury of two Huntington's disease (HD) transgenic mice: R6/1 and R6/1:BDNF(+/-). We found that R6/1:BDNF(+/-) mice--which express reduced levels of BDNF--were more resistant than R6/1 mice to intrastriatal injection of quinolinate. This increased resistance is related to a differential reduction in expression of NMDAR scaffolding proteins,...

Topics

Adult
Aged
Animals
Corpus Striatum
Humans
Huntingtin Protein
Male
Mice
Mice, Transgenic
Mutation
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Receptors, Glutamate

Receptors, N-Methyl-D-Aspartate

Signal Transduction

Synapses

Synaptic Transmission

Source

Open in PubMed

Identifiers

PMID: 18063376
DOI: 10.1016/j.nbd.2007.10.003

Genes

PSD
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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