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Article

Excess growth hormone suppresses DNA damage repair in epithelial cells

6 Feb 2019

Abstract excerpt

Growth hormone (GH) decreases with age, and GH therapy has been advocated by some to sustain lean muscle mass and vigor in aging patients and advocated by athletes to enhance performance. Environmental insults and aging lead to DNA damage, which - if unrepaired - results in chromosomal instability and tumorigenesis. We show that GH suppresses epithelial DNA damage repair and blocks ataxia telangiectasia mutated...

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PMID: 30728323
DOI: 10.1172/jci.insight.125762

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