Article
Effect of streptavidins with varying biotin binding affinities on the properties of biotinylated gramicidin channels.
Biochemistry - 20 Apr 2004
Antonenko Y N, Rokitskaya T I, Kotova E A, Reznik G O, Sano T, Cantor C R
Abstract excerpt
The pentadecapeptide gramicidin A, which is known to form highly conductive ion channels in a bilayer lipid membrane by assembling as transmembrane head-to-head dimers, can be modified by attaching a biotin group to its C-terminus through an aminocaproyl spacer. Such biotinylated gramicidin A analogues also form ion channels in a hydrophobic lipid bilayer, exposing the biotin group to the aqueous bathing...
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