Article
Design and characterization of gramicidin channels with side chain or backbone mutations.
Novartis Foundation symposium - 1 Jan 1999
Koeppe R E, Greathouse D V, Providence L L, Shobana S, Andersen O S
Abstract excerpt
Mutations and chemical substitutions of amino acid side chains and backbone atoms have proved vital for understanding the folding, structure and function of gramicidin channels in phospholipid membranes. The channel's pore is lined by peptide backbone groups; their importance for channel structure and function is shown by a single amide-to-ester replacement within the backbone, which greatly reduces the resulting...
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