Article
Interactions of high-affinity cationic blockers with the translocation pores of B. anthracis, C. botulinum, and C. perfringens binary toxins.
Biophysical journal - 19 Sept 2012
Bezrukov Sergey M, Liu Xian, Karginov Vladimir A, Wein Alexander N, Leppla Stephen H, Popoff Michel R, Barth Holger, Nestorovich Ekaterina M
Abstract excerpt
Cationic β-cyclodextrin derivatives were recently introduced as highly effective, potentially universal blockers of three binary bacterial toxins: anthrax toxin of Bacillus anthracis, C2 toxin of Clostridium botulinum, and iota toxin of Clostridium perfringens. The binary toxins are made of two separate components: the enzymatic A component, which acts on certain intracellular targets, and the...
Topics
- Bacillus anthracis
- Bacterial Toxins
- Biological Transport
- Clostridium botulinum
- Clostridium perfringens
- Dose-Response Relationship, Drug
- Electric Conductivity
- Kinetics
- Mutation
- Porosity
- Potassium Chloride
- Protein Binding
- beta-Cyclodextrins