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Article

p53 and microRNA-34 are suppressors of canonical Wnt signaling.

Science signaling - 1 Nov 2011

Kim Nam Hee, Kim Hyun Sil, Kim Nam-Gyun, Lee Inhan, Choi Hyung-Seok, Li Xiao-Yan, Kang Shi Eun, Cha So Young, Ryu Joo Kyung, Na Jung Min, Park Changbum, Kim Kunhong, Lee Sanghyuk, Gumbiner Barry M, Yook Jong In, Weiss Stephen J

Abstract excerpt

Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain unclear. We report that p53 transactivated microRNA-34 (miR-34), which consequently suppressed the transcriptional activity of β-catenin-T cell factor and lymphoid enhancer factor (TCF/LEF) complexes by targeting the untranslated regions (UTRs) of a set of...

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Identifiers

PMID: 22045851
DOI: 10.1126/scisignal.2001744
PMCID: PMC3447368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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