Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased seizure threshold in mice lacking aquaporin-4 water channels.

Neuroreport - 9 Feb 2004

Binder Devin K, Oshio Kotaro, Ma Tonghui, Verkman A S, Manley Geoffrey T

Abstract excerpt

Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge. In this report, we tested seizure susceptibility in AQP4 mice. AQP4 mice and wild-type controls were given the chemoconv...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Aquaporin 4
Share to Aquaporins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Edema

Share to Electroencephalography

Share to Membrane Potentials

Share to Pentylenetetrazole

Share to Reaction Time

Source

Identifiers

PMID: 15076748
DOI: 10.1097/00001756-200402090-00009

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15076748-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased seizure threshold in mice lacking aquaporin-4 water channels.PMID 15076748Read ↗

New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.Semantic proximity Read ↗

Effects of constitutive and acute Connexin 36 deficiency on brain-wide susceptibility to PTZ-induced neuronal hyperactivitySemantic proximity Read ↗

Potential utility of aquaporin modulators for therapy of brain disorders.Semantic proximity Read ↗

Greatly improved survival and neuroprotection in aquaporin‐4‐knockout mice following global cerebral ischemiaSemantic proximity Read ↗

Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.Semantic proximity Read ↗

Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.Semantic proximity Read ↗

Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor.Semantic proximity Read ↗

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.Semantic proximity Read ↗

Aquaporin-4 Gene Disruption in Mice Reduces Brain Swelling and Mortality in Pneumococcal MeningitisSemantic proximity Read ↗

Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4.Semantic proximity Read ↗

Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral MalariaSemantic proximity Read ↗

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.