Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.

European journal of pharmacology - 15 Aug 2024

Silva-Cardoso Gleice K, Boda Vijay K, Li Wei, N'Gouemo Prosper

Abstract excerpt

Transient receptor potential canonical 3 (TRPC3) channels are important in regulating Ca2+ homeostasis and have been implicated in the pathophysiology of chemically induced seizures. Inherited seizure susceptibility in genetically epilepsy-prone rats (GEPR-3s) has been linked to increased voltage-gated Ca2+ channel currents in the inferior colliculus neurons, which can affect intraneuronal Ca2+ homeostasis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Epilepsy
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Seizures

Share to TRPC Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 38851562
DOI: 10.1016/j.ejphar.2024.176722
PMCID: PMC11295865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.PMID 38851562Read ↗

Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat.Semantic proximity Read ↗

Seizure susceptibility is associated with altered protein expression of voltage-gated calcium channel subunits in inferior colliculus neurons of the genetically epilepsy-prone rat.Semantic proximity Read ↗

Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models.Semantic proximity Read ↗

Neuronal networks in the genetically epilepsy-prone rat.Semantic proximity Read ↗

Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats.Semantic proximity Read ↗

Animal models in EpilepsySemantic proximity Read ↗

Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility.Semantic proximity Read ↗

Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures.Semantic proximity Read ↗

Effects of constitutive and acute Connexin 36 deficiency on brain-wide susceptibility to PTZ-induced neuronal hyperactivitySemantic proximity Read ↗

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the <scp>GAERS</scp> model of genetic generalized epilepsySemantic proximity Read ↗

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility.Semantic proximity Read ↗

Voluntary Control of Epileptiform Spike–Wave Discharges in Awake RatsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.