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Article

Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013

Suidan Georgette L, Brill Alexander, De Meyer Simon F, Voorhees Jaymie R, Cifuni Stephen M, Cabral Jessica E, Wagner Denisa D

Abstract excerpt

OBJECTIVE: Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of VWF in endothelial homeostasis is unclear. The goal of this study was to assess the role of VWF in disease models associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23825365
DOI: 10.1161/ATVBAHA.113.301362
PMCID: PMC3854012

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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