Depolymerization of aquaporin-4 orthogonal array particles via the A25Q mutation does not cause behavioral deficits but confers resilience to chronic unpredictable mild stress.

Abstract excerpt

Aquaporin-4 (AQP4) formed orthogonal array particles (OAPs) is critical for brain water homeostasis and astrocytic function, but whether OAP structural integrity influences behavior or stress susceptibility is unknown. Using knock-in mice carrying the AQP4-A25Q mutation, which depolymerizes OAPs without altering AQP4 expression, we investigated baseline behavior and responses to chronic unpredictable mild stress...

Topics

• Animals
• Aquaporin 4
• Stress, Psychological
• Mice
• Male
• Mutation