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Article

Polymorphism, heteroplasmy, mitochondrial fusion and diabetes.

Bioscience reports - 1 Jan 2000

Sato Aya, Endo Hitoshi, Umetsu Kazuo, Sone Hideyuki, Yanagisawa Yoshiko, Saigusa Azusa, Aita Sayuri, Kagawa Yasuo

Abstract excerpt

Mitochondrial DNA (mtDNA) is highly susceptible to mutations that result in polymorphisms and diseases including diabetes. We analyzed heteroplasmy, polymorphisms related to diabetes, and complementation by fusogenic proteins. Cytoplast fusion and microinjection allow, defects in mutated mtDNA inside a heteroplasmic cell to be complemented by fusing two mitochondria via human fusogenic proteins. We characterized...

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Identifiers

PMID: 15074546
DOI: 10.1023/b:bire.0000019189.35983.b9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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