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Article

Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.

British journal of cancer - 6 Jul 2001

Ueda M, Gemmill R M, West J, Winn R, Sugita M, Tanaka N, Ueki M, Drabkin H A

Abstract excerpt

Beta-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator in the Wnt signalling pathway. Although recent investigations have been focused on the role of the adenomatous polyposis coli (APC)/ beta-catenin/Tcf pathway in human tumorigenesis, there have been very f...

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Source

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Identifiers

PMID: 11437403
DOI: 10.1054/bjoc.2001.1863
PMCID: PMC2363927

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11437403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.PMID 11437403Read ↗

Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion.Semantic proximity Read ↗

APC mutations are infrequent but present in human lung cancer.Semantic proximity Read ↗

No evidence for involvement of beta-catenin and APC in urothelial carcinomas.Semantic proximity Read ↗

Non-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases.Semantic proximity Read ↗

No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas.Semantic proximity Read ↗

Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas.Semantic proximity Read ↗

Beta-catenin mutations in cell lines established from human colorectal cancers.Semantic proximity Read ↗

Frequent alterations of the beta-catenin protein in cancer of the uterine cervix.Semantic proximity Read ↗

Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.Semantic proximity Read ↗

Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis.Semantic proximity Read ↗

Beta-catenin gene analysis in oral squamous cell carcinoma.Semantic proximity Read ↗

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