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Article

In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2004

Geoffroy Valérie, Marty-Morieux Caroline, Le Goupil Nathalie, Clement-Lacroix Phillippe, Terraz Catherine, Frain Monique, Roux Sophie, Rossert Jérome, de Vernejoul Marie Christine

Abstract excerpt

UNLABELLED: Mice specifically overexpressing TIMP-1 in osteoblasts have been generated to investigate the role of MMPs in bone in vivo. These mice displayed increased trabecular bone volume and decreased bone turnover. This model provides evidence of the role played by the MMPs in bone remodeling and balance. INTRODUCTION: Although it has been suggested that the matrix metalloproteinases (MMPs) may play a role in...

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Source

Identifiers

PMID: 15068505
DOI: 10.1359/JBMR.040119

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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