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Article

Dissociation between bone resorption and bone formation in osteopenic transgenic mice

10 Nov 1998

Abstract excerpt

Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells...

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PMID: 9811887
DOI: 10.1073/pnas.95.23.13835

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