Article
Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.
The FEBS journal - 1 Sept 2013
Lee C Y Daniel, Cantle Jeffrey P, Yang X William
Abstract excerpt
This year (2013) marks the 20th anniversary of identification of the causal genetic mutation for Huntington's disease (HD), a landmark discovery that heralded study of the biological underpinnings of this most common dominantly inherited neurodegenerative disorder. Among the variety of model organisms used to study HD pathogenesis, the mouse model is by far the most commonly used mammalian genetic model. Much of...
Topics
- Animals
- Caspase 6
- Cerebral Cortex
- Corpus Striatum
- Disease Models, Animal
- Gene Expression Regulation
- Humans
- Huntingtin Protein
- Huntington Disease
- Mice
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins
- Neurons
- Nuclear Proteins
- Protein Engineering
- Protein Structure, Tertiary
- Signal Transduction