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Article

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.

The FEBS journal - 1 Sept 2013

Lee C Y Daniel, Cantle Jeffrey P, Yang X William

Abstract excerpt

This year (2013) marks the 20th anniversary of identification of the causal genetic mutation for Huntington's disease (HD), a landmark discovery that heralded study of the biological underpinnings of this most common dominantly inherited neurodegenerative disorder. Among the variety of model organisms used to study HD pathogenesis, the mouse model is by far the most commonly used mammalian genetic model. Much of...

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Identifiers

PMID: 23829302
DOI: 10.1111/febs.12418
PMCID: PMC3770892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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