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Article

Clinical impact of internal tandem duplications and activating point mutations in <i>FLT3</i> in acute myeloid leukemia in elderly patients

1 Apr 2004

Abstract excerpt

BACKGROUND: The FLT3 gene is frequently mutated in acute myeloid leukemia (AML), either by an internal tandem duplication (ITD) of the juxtamembrane domain or by activating point mutations in the second tyrosine kinase domain (ATKD). Only a few investigations have focused on the prognostic significance of FLT3 alterations in AML among the elderly, yielding conflicting results. In the present study, the frequency...

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PMID: 15059064
DOI: 10.1111/j.1600-0609.2004.00225.x

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Clinical impact of internal tandem duplications and activating point mutations in <i>FLT3</i> in acute myeloid leukemia in elderly patientsPMID 15059064Read ↗

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