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Article

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.

The Journal of biological chemistry - 21 Dec 2007

Chen Juxing, Chloupková Maja, Gao Junwei, Chapman-Arvedson Tara L, Enns Caroline A

Abstract excerpt

Mutations in the transmembrane glycoproteins transferrin receptor 2 (TfR2) and HFE are associated with hereditary hemochromatosis. Interactions between HFE and transferrin receptor 1 (TfR1) have been mapped to the alpha1- and alpha2-helices in HFE and to the helical domain of TfR1. Recently, TfR2 was also reported to interact with HFE in transfected mammalian cells. To test whether similar HFE residues are...

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Share to Antigens, CD
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to HLA-B7 Antigen

Share to Peptide Mapping

Share to Receptors, Transferrin

Source

Identifiers

PMID: 17956864
DOI: 10.1074/jbc.M706720200

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.PMID 17956864Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.Semantic proximity Read ↗

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand bindingSemantic proximity Read ↗

Regulation of transferrin receptor 2 protein levels by transferrinSemantic proximity Read ↗

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfaceSemantic proximity Read ↗

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