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Article

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.

Nature - 6 Jan 2000

Bennett M J, Lebrón J A, Bjorkman P J

Abstract excerpt

HFE is related to major histocompatibility complex (MHC) class I proteins and is mutated in the iron-overload disease hereditary haemochromatosis. HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin. The 2.8 A crystal structure of a complex between the extracellular portions of HFE and TfR shows two HFE molecules which grasp each side of a twofold symmetric TfR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10638746
DOI: 10.1038/47417

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.PMID 10638746Read ↗

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HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfaceSemantic proximity Read ↗

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