Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanocortin-4 receptor: a novel signalling pathway involved in body weight regulation.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Feb 1999

Fisher S L, Yagaloff K A, Burn P

Abstract excerpt

For many years, genetically obese mouse strains have provided models for human obesity. The Avy/-agouti mouse, one of the oldest obese mouse models, is characterized by maturity-onset obesity and diabetes as a result of ectopic expression of the secreted protein hormone, agouti protein. Agouti protein is normally expressed in hair follicles to regulate pigmentation through antagonism of the melanocortin-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Leptin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Models, Biological

Share to Obesity

Share to Proteins

Share to Receptor, Melanocortin, Type 4

Share to Receptors, Peptide

Source

Identifiers

PMID: 10193863
DOI: 10.1038/sj.ijo.0800796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanocortin-4 receptor: a novel signalling pathway involved in body weight regulation.PMID 10193863Read ↗

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related ProteinSemantic proximity Read ↗

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.Semantic proximity Read ↗

Pro-opiomelanocortin and weight regulation: from mice to men.Semantic proximity Read ↗

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.Semantic proximity Read ↗

The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity.Semantic proximity Read ↗

Agouti/melanocortin interactions with leptin pathways in obesity.Semantic proximity Read ↗

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in MiceSemantic proximity Read ↗

The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse modelsSemantic proximity Read ↗

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.Semantic proximity Read ↗

The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Semantic proximity Read ↗

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.Semantic proximity Read ↗

The melanocortin action is biased toward protection from weight loss in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.